Mini Stem Cell Transplant For Myelofibrosis

It is beneficial to improve the outcomes of this procedure in myelofibrosis.

Mini stem cell transplant for myelofibrosis. Despite the approval of janus kinase inhibitor treatment in myelofibrosis allogeneic stem cell transplantation remains the only curative treatment option for myelofibrosis whereas the transplant procedure itself still has high therapy related morbidity and mortality despite recent improvements. Allogeneic stem cell transplantation for myelofibrosis in 2012 donal p. Bone marrow transplantation is a treatment procedure in which damaged or faulty bone marrow is replaced by healthy bone marrow from a donor. Allogeneic stem cell transplantation is the only current treatment with the potential to cure mf but it also carries a high risk of life threatening side effects.

Stem cell transplantation. Myelofibrosis mf is a clonal myeloproliferative neoplasm mpn that can arise de novo or result from previous polycythemia vera or essential thrombocythemia post et mf. Hematopoietic cell transplantation as curative therapy for idiopathic myelofibrosis advanced polycythemia vera and essential thrombocythemia. A reduced intensity non myeloablative or mini transplant is a conditioning process in which lower doses of chemotherapy and or radiation or none at all are given prior to stem cell transpla.

If left untreated it could turn into leukemia. For myelofibrosis the procedure uses stem cells from a donor allogeneic stem cell transplant. A bone marrow aspiration revealed i d developed myelofibrosis a type of bone cancer. Mf is characterized by a clonal stem cell process resulting in ineffective erythropoiesis reactive fibrosis in bone marrow and extramedullary hematopoiesis in the spleen or in multiple organs 1.

My sister was only a 50 match. British journal of haematology 29 march 2012 sources. Some mf patients present to the transplant center with severe complications after a long disease history and their treatment may be very challenging. A stem cell transplant is the only treatment that can cure myelofibrosis.

Myelofibrosis is typically treated with a stem cell transplant so i started working with uday popat m d to find a donor. Treating my myelofibrosis with a stem cell transplant. And because of the variable outcome of patients with myelofibrosis treatment decision with. It is usually risky for older patients and those individuals with other health problems.

1 recently reported a significant improvement in outcome of patients with myelofibrosis mf after allogeneic stem cell transplantation sct. This treatment has the potential to cure myelofibrosis but it also carries a high risk of life threatening side effects including a risk that the new stem cells will react against your body s healthy tissues graft versus host disease.